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Selectivity & Sensitivity of Chiroptical Methods

Technique Selectivity Sensitivity Quantified By Improved By

In short

• ORD = broad chirality probe, low sensitivity

• CD = more detailed, higher sensitivity, chromophore-specific

• FDCD = extremely sensitive and highly selective, but only works with fluorescent chromophores.

• CPL = detects circular polarization in emitted light, revealing chiral information from excited states (useful for luminescent or emissive systems).