The history, philosophy, and people

 behind the Brilliant Breakthroughs made since the 1970s

Company History

Founded in the 1970s by then tenured professor of biochemistry, Dr. Richard J. DeSa...

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Dr. Richard J. DeSa

Dick DeSa, or “Chief” as he is widely known, has devoted his life to instrument...

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Julie DeSa Lorenz

Owner and CEO of the company founded by her father…

Technical Support

Elisabeth Millsap, our Customer Support Engineer, prioritizes…

 

 If it were easy, everyone would build instruments from the software up.

Researchers are not generally instrumentalists. They have to trust manufacturers to produce and support the instruments that have direct and inescapable consequences for their careers.

Most manufacturers want to mass produce instruments to a wide audience. Designed-in obsolescence is a given. Innovation and excellence are rare.

And then there is our way. Where innovation and excellence are the norm and instruments are endlessly upgradable. Our powerful implementation of software is a key factor. Computerizing research spectrophotometers was our only focus from 1976-1991.

We joke with real seriousness that “Hardware is a complication that houses the sample and produces the signal. Everything else should be done by a computer.”

 

Some of the people behind your instruments:

Richard Hantus
CAD Engineer & Production Lead

Robin Crenshaw
Master Machinist

Matthew Paulishen
Electronic Wngineer

Tseliso Campell
Production

 

James Thaxton
Inventory and Production

Elisabeth Millsap
Customer Support Engineer

Janice Donald
Production Coordinator

 
 
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Paper authored by our founder, Dr. Richard DeSa, in 1969. See this paper and more on his ResearchGate page.

 

 An unattractive aspect of research is the unavoidable waste. How can you reduce your carbon footprint without downside?  Let me share five ways here:

 

1. Instead of discarding a spectrophotometer and buying something new, upcycle what you own. 

2. Instead of buying a spectrophotometer built from scratch, buy one upcycled from a great classic or destined to become one.

3. Instead of doing many repeat experiments to improve S/N, purchase a higher sensitivity spectrophotometer.

4. Instead of doing kinetic studies at single wavelengths, do them at multiple wavelengths. 

5. Instead of investing resources into creating a protein solution from organisms, measure the protein activity within the organism.

Instead of buying your instruments from a corporation that cares about their profits and not your waste, buy from a company committed to brilliant breakthroughs and softer carbon footprints.

 

Developer, Dr. Richard J. DeSa, with an Olis CLARiTY

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From Antonio Peña, October 2017:

It is hard for me to remember when exactly I had the fortune, first to hear from Dr. DeSa, and then meet him in person, and mostly to be able to take advantage of the technology he has developed for so many years. Particularly during the first years, there was the additional pleasure of knowing that all the excellent products and services provided by OLIS Inc were supported by a family enterprise.

 Through the years, not only my laboratory, but others in our Institute and other places in Mexico, had acquired high precision spectrophotometers as well as spectrofluorometers invented by Britton Chance. However, in a few years we saw the disappearance of brands like Aminco, SLM, American Optical, and finally nothing… so, the only possible future for

our instruments was that they lasted forever, without any hope for service. But one day we heard about a new company, OLIS Instruments. It sounded unbelievable, because it not only would allow us to preserve our instruments, but more so, have them modernized, with a computer attached, allowing us to forget about the use of pen recorders, but also, through the years, enjoy the growing possibilities to process the data and refined our findings.

So we started to seek for the funds necessary to modernize our equipments, and in the process, for some reason, one day we decided to go to Bogart GA and see by ourselves the origin and structure of that miracle. We were surprised at first, the place was not very small, but also not that of the very large companies we were used to see. But perhaps the most pleasant an original surprise was that OLIS Inc was an enterprise, requiring of course, the mastermind of Richard DeSa, who progressively moved from the modernization of different types of equipments, to develop more and more elaborate ones, such as the RSM 1000, and the most recent, the OLIS CLARiTY. But most interesting was that, particularly during its first years, OLIS was operated by a group which is not only remarkable as such, but a wonderful family followed by an extraordinary community.

I want to mention a particular experience with Dr. DeSa: while trying to get the modernization of one of our equipment, we could not raise the funds to complete the full cost. I wrote him, and he gave me a very substantial discount, for which I have always been grateful, but also shows one of his important personal characteristics: generosity before business.

With the modernization of our first spectrophotometer we had the fortune that the whole modification was installed by Richard DeSa himself, who came with his wife, and had the opportunity to visit the pyramids of Teotihuacan. It has been many years that we have enjoyed the attention, support and kindness, not only from the DeSa’s, but also from each and everyone, not employees, but members of a community. So, I end up by wishing the best to OLIS, but more than that, to the wonderful DeSa family and thanking heaven for having put them in my way, an all my admiration to Richard DeSa.

 

“Nothing tends so much to the advancement of knowledge as the application of a new instrument.”

— Sir Humphrey Davy. 1812 

 
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When it came time for us to develop and produce hardware, we did so only to offer something better markedly better than what was available. Why re-invent the wheel or make modest improvements when new instruments offer so much more?

 

Founder: Dr. Richard J. DeSa

Our First Spectrophotometer:
the OLIS RSM 1000

This one millisecond spectrum was collected on the prototype, circa 1992.

This one millisecond spectrum was collected on the prototype, circa 1992.

 This one millisecond spectrum was collected on the prototype, circa 1992.

Look at this high-resolution spectrum, collected in 1992. What is special about it? It was collected in one millisecond.  Software written by the highest caliber scientists and software developers over a nearly five year period was required to handle the megabyte of data per second the RSM produces.

This OLIS RSM 1000 remains the only rapid-scanning monochromator in existence. With it, you can answer questions impossible on ‘normal’ spectrophotometers. It easily gives you milliabsorbance sensitivity and millisecond spectral acquisition rates, and single keystroke software steps for 3D analysis.

A Brilliant Breakthrough by anyone’s criteria, this spectrophotometry system collects a megabyte of data per second for highest density data acquisition from minimal sample.  

 Another brilliant breakthrough product that could lead to your brilliant breakthroughs: the CLARiTY.

Clear samples are easy. Every UV/Vis, NIR, and IR spectrophotometer handles clear samples.

In 2009, Dr. De Sa took on the challenge of expanding your experimental opportunities to include turbid samples.

He called the prototype the “Mitochondria Machine,” as proof of performance was achieved following the electron transport chain in living cells!  The RSM was slowed to 100 scans per second.

In 2009, while developing the first CLARiTY, Dr. DeSa could frequently be heard muttering:

In 2009, while developing the first CLARiTY, Dr. DeSa could frequently be heard muttering:

 CLARiTY Systems for a Wider Audience

Many applications cannot take advantage of the high-speed scanning. The CLARiTY technology is now available on upcycled Cary and OLIS spectrophotometers, as well as a modestly priced CCD version. Most recently, models for single wavelength applications were added, too!

OLIS CLARiTY 1

OLIS CLARiTY 1

 

Circularly Polarized Luminescence!

A new luminescence spectrometer was added in 2019 that brings circularly polarized luminescence spectroscopy within reach of most laboratories. Everyone knows about fluorimeters for measuring molecules in their excited state. And CD spectrometer for measuring chiral molecules in their ground state.  Now, you have the opportunity to expand your science to include chiral molecules in their excited state!

OLIS CPL Solo

OLIS CPL Solo

Today, we offer you a full line of UV/Vis and NIR absorbance, fluorescence, circular dichroism, circularly polarized luminescence, and phosphorescence lifetime spectrometers, all of which expand your opportunities for worthwhile measurements, lower cost experiments, and your best opportunity for brilliant breakthroughs.

 

 In 1998, we ran this advertisement in the 75th Anniversary issue of C&E News to celebrate 22 years in business.  This photo shows that the very first delivered product under the OLIS name, a (mini) computer system DeSa and his early partners produced to improve — to upcycle — a spectrophotometer at the University of Michigan.

It’s now 2021, so another 22 years of brilliant breakthroughs are under our belt.

 Is it time for you to join us?

  • Best results with least sample

  • Highest technology hardware & software

  • Endlessly upgradable spectrophotometers

  • Technical support that puts your needs first

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